Grants Awarded

Assesment of PTPN6 (SHP-1) in Langerhans Cell Line

Principal Investigators
Ichiro Murakami MD, PhD and Takashi Oka PhD
Tottori University – Yonago-shi, Japan

Date of Award
November 2009

Amount of Award

Layperson Summary
Phosphatases work as brakes in cell proliferation. Kinases work as accelerators. Over-expression of kinases or down-regulation of phosphatases are relevant for proliferative disorders. We presented on the strange phenomenon of the over-expression of phosphatases (SHP-1) in LCH at the 2008 Histiocyte Society Annual Meeting. We are going to transfect the SHP-1 gene to LC cell line and analyze what will happen by transfection.

Twelve Month Report

Gene Expression of PTPN6 (SHP-1) Transfected Langerhans Cell-Like Cell Line (ELD-1) -Compared With Open Data of LCH Substype (GSE16395)
Ichiro Murakami, Takashi Oka, Kazuhiko Hayashi, Jean Gogusev, Francis Jaubert, Akira Morimoto, Shinsaku Imashuku, Tadashi Yoshino

IL-17A Receptor Expression Differs Between Subclasses of Langerhans Cell Histiocytosis, Which Might Settle the IL-17A Controversy
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T.
Virchows Arch
. 2013 Feb;462(2):219-28. doi: 10.1007/s00428-012-1360-6. Epub 2012 Dec 27.