Assesment of PTPN6 (SHP-1) in Langerhans Cell Line
Ichiro Murakami MD, PhD and Takashi Oka PhD
Tottori University – Yonago-shi, Japan
Date of Award
Amount of Award
Phosphatases work as brakes in cell proliferation. Kinases work as accelerators. Over-expression of kinases or down-regulation of phosphatases are relevant for proliferative disorders. We presented on the strange phenomenon of the over-expression of phosphatases (SHP-1) in LCH at the 2008 Histiocyte Society Annual Meeting. We are going to transfect the SHP-1 gene to LC cell line and analyze what will happen by transfection.
Twelve Month Report
Gene Expression of PTPN6 (SHP-1) Transfected Langerhans Cell-Like Cell Line (ELD-1) -Compared With Open Data of LCH Substype (GSE16395)
Ichiro Murakami, Takashi Oka, Kazuhiko Hayashi, Jean Gogusev, Francis Jaubert, Akira Morimoto, Shinsaku Imashuku, Tadashi Yoshino
IL-17A Receptor Expression Differs Between Subclasses of Langerhans Cell Histiocytosis, Which Might Settle the IL-17A Controversy
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T.
Virchows Arch. 2013 Feb;462(2):219-28. doi: 10.1007/s00428-012-1360-6. Epub 2012 Dec 27.