Identification of Lytic Granule Exocytosis-Related Candidate Genes Involved in Pathogenesis of Hemophagocytic Lymphohistiocytosis
Principal Investigator and Co-Investigator
Sasa Radoja PhD (PI) and E. Marion Schneider PhD
Children’s Research Institute – Washington, District of Columbia USA
Date of Award
Amount of Award
Hemophagocytic lymphohistiocytosis (HLH) is a life threatening immune disorder that usually presents during infancy or early childhood. Dysfunction of a particular type of immune cells, called “killer cells” is thought to be the basis for development of HLH. By comparing the blood samples from HLH patients and healthy individuals, our goal is to find new genes that are responsible for altered function of the killer cells in HLH patients. We believe that findings originating from the studies proposed in this application will allow us to better understand how this disease develops and eventually help us find more efficient ways for its treatment.