Grants Awarded

HLH/FEL/FHL
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  • All
  • HLH/FEL/FHL
  • LCH
  • Rare Histiocytic Disorders and Other Topics

Excessive IL-10 Potentiates IL-18 to Cooperatively Drive Severe Secondary HLH/MAS-like Disease and Hyper-inflammaphagocytic Macrophage Polarization in Mouse Models.

Gang Huang Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA

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Use of a Response-Adapted Ruxolitinib-Containing Regimen for the Treatment of Hemophagocytic Lymphohistiocytosis

Melissa Hines St Jude Children’s Research Hospital, Memphis, TN USA

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Understanding the role of Epstein Barr virus in Hemophagocytic Lymphohistiocytosis

Principal Investigator Claire Shannon-Lowe The University of Birmingham Birmingham, United Kingdom Date of Award December 2018 Amount of…

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Unbiased profiling of the hemophagocytic lymphohistiocytic syndrome by high-throughput single-cell transcriptomic analysis

Principal Investigator Fernando Sepulveda INSERM DR Paris 5 Paris, France Date of Award December 2018 Amount of Award…

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The mechanisms of cytotoxic granule exocytosis underlying hemophagocytic lymphohistiocytosis

Principal Investigator Shuzo Sugita University Health Network Toronto, ON Canada Date of Award December 2018 Amount of Award…

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The use of a newly generated murine model to determine the broad role of STXBP2 in FHL5 pathogenesis

Principal Investigator Fernando Sepulveda, Ph.D. Imagine Institute Paris, France Date of Award December 2016 Amount of Award…

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HIF-1α Signaling is a Central Pathobiologic Mediator of Hemophagocytic Lymphohistiocytosis

Principal Investigator Gang Huang, Ph.D. Children’s Hospital Medical Center Cincinnati, OH USA Date of Award December 2016…

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Genetic Defects in Cytolysis in Patients with Macrophage Activation Syndrome Enrolled in a Clinical Trial to Explore Interleukin-1 Blockage Therapy

Principal Investigator Randy Cron, M.D., Ph.D. University of Alabama at Birmingham Birmingham, AL USA Date of Award…

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Identification of Molecular Mechanisms Underlying Defective Cytotoxic Lymphocyte Function in Chediak-Higashi Syndrome, a Histiocytic Lysosomal Storage Disorder with Immunodeficiency

Principal Investigator Konrad Krzewski, PhD National Institute of Allergy and Infectious Diseases, National Institutes of Health Rockville,…

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Genetic Dissection of the Exocytic Machinery in Cytotoxic Lymphocytes

Principal Investigator Matthias Voss, PhD Karolinska Institutet Stockholm, Sweden   Date of Award December 2015 Amount of…

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