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- HLH/FEL/FHL
- LCH
- Rare Histiocytic Disorders and Other Topics
Excessive IL-10 Potentiates IL-18 to Cooperatively Drive Severe Secondary HLH/MAS-like Disease and Hyper-inflammaphagocytic Macrophage Polarization in Mouse Models.
Gang Huang Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA
Use of a Response-Adapted Ruxolitinib-Containing Regimen for the Treatment of Hemophagocytic Lymphohistiocytosis
Melissa Hines St Jude Children’s Research Hospital, Memphis, TN USA
Understanding the role of Epstein Barr virus in Hemophagocytic Lymphohistiocytosis
Principal Investigator Claire Shannon-Lowe The University of Birmingham Birmingham, United Kingdom Date of Award December 2018 Amount of…
Unbiased profiling of the hemophagocytic lymphohistiocytic syndrome by high-throughput single-cell transcriptomic analysis
Principal Investigator Fernando Sepulveda INSERM DR Paris 5 Paris, France Date of Award December 2018 Amount of Award…
The mechanisms of cytotoxic granule exocytosis underlying hemophagocytic lymphohistiocytosis
Principal Investigator Shuzo Sugita University Health Network Toronto, ON Canada Date of Award December 2018 Amount of Award…
The use of a newly generated murine model to determine the broad role of STXBP2 in FHL5 pathogenesis
Principal Investigator Fernando Sepulveda, Ph.D. Imagine Institute Paris, France Date of Award December 2016 Amount of Award…
HIF-1α Signaling is a Central Pathobiologic Mediator of Hemophagocytic Lymphohistiocytosis
Principal Investigator Gang Huang, Ph.D. Children’s Hospital Medical Center Cincinnati, OH USA Date of Award December 2016…
Genetic Defects in Cytolysis in Patients with Macrophage Activation Syndrome Enrolled in a Clinical Trial to Explore Interleukin-1 Blockage Therapy
Principal Investigator Randy Cron, M.D., Ph.D. University of Alabama at Birmingham Birmingham, AL USA Date of Award…
Identification of Molecular Mechanisms Underlying Defective Cytotoxic Lymphocyte Function in Chediak-Higashi Syndrome, a Histiocytic Lysosomal Storage Disorder with Immunodeficiency
Principal Investigator Konrad Krzewski, PhD National Institute of Allergy and Infectious Diseases, National Institutes of Health Rockville,…
Genetic Dissection of the Exocytic Machinery in Cytotoxic Lymphocytes
Principal Investigator Matthias Voss, PhD Karolinska Institutet Stockholm, Sweden Date of Award December 2015 Amount of…