Grants Awarded

HLH/FEL/FHL
All
  • All
  • ECD
  • HLH/FEL/FHL
  • JXG
  • LCH
  • Rare Histiocytic Disorders and Other Topics
  • RDD

Validation and Implementation of a Novel Tool for Predicting Pathogenicity of Variants of Uncertain Significance in Familial Hemophagocytic Lymphohistiocytosis Genes

Principal Investigator: Kim Nichols St. Jude Children’s Hospital, Memphis,Tennesse,USA Date of Award: December 2024 Amount of Award:…

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Prime editing-based correction of UNC13D

Principal Investigator: Dr. Toni Cathomen Medical Center – University of Freiburg Breisgau, Germany Date of Award: December…

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Evaluation of protein arginine methyltransferase 5 (PRMT5) as an actionable target in hemophagocytic lymphohistiocytosis (HLH)

Principal Investigator: Polina Shindiapina Ohio State University Columbus, OH USA Date of Award: December 2023 Amount of Award: $50,000…

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DOCK Genes: Novel Risk Alleles for Cytokine Storm Syndrome

Principal Investigator: Randy Cron University of Alabama at Birmingham Brimingham, AL USA  Date of Award: December 2023 Award Amount:…

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Defining the pathophysiology of HLH in Hematologic Malignancies

Principal Investigator: Dr. Michael Jordan Cincinnati Children’s Hospital Medical Center Cincinatti, OH Date of Award: December 2022 Amount…

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Defining and Testing the Hyperinflammatory Immune Synapse

Principal Investigator: Dr. Scott Canna Children’s Hospital of Philadelphia Philadelphia, PA Date of Award: December 2022 Amount…

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Immunoproteasome inhibition as a novel therapy for hemophagocytic lymphohistiocytosis (HLH)

Principal Invesigator: Dr. Kim Nichols St. Jude Children’s Research Hospital Memphis, TN Date of Award: December 2022…

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Role of the immune checkpoint TIM-3 in the pathogenesis of non-classical HLH

Principal Investigator Dr. Fernando Sepulveda Imagine Institute Paris, FR Date of Award December 2021 Amount of Award…

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Identifying novel CSF Biomarkers for the Diagnosis of Isolated CNS Hemophagocytic Lymphohistiocytosis

Principal Investigator Dr. Sharat Chandra Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio USA Date of Award December…

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Excessive IL-10 Potentiates IL-18 to Cooperatively Drive Severe Secondary HLH/MAS-like Disease and Hyper-inflammaphagocytic Macrophage Polarization in Mouse Models.

Gang Huang Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA

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