Grants Awarded

HLH/FEL/FHL
All
  • All
  • HLH/FEL/FHL
  • LCH
  • Rare Histiocytic Disorders and Other Topics

Identification of Molecular Mechanisms Underlying Defective Cytotoxic Lymphocyte Function in Chediak-Higashi Syndrome, a Histiocytic Lysosomal Storage Disorder with Immunodeficiency

Principal Investigator Konrad Krzewski, PhD National Institute of Allergy and Infectious Diseases, National Institutes of Health Rockville,…

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Genetic Dissection of the Exocytic Machinery in Cytotoxic Lymphocytes

Principal Investigator Matthias Voss, PhD Karolinska Institutet Stockholm, Sweden   Date of Award December 2015 Amount of…

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Deciphering the Underlying Molecular Defects in CTL and NK Cell Cytotoxicity in FHL Patients

Principal Investigator Claudio Giraudo, PhD The Children’s Hospital of Philadelphia University of Pennsylvania Philadelphia, Pennsylvania USA Date…

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Gaining Insights into the Mechanisms of Lymphocyte Cytotoxicity Underlying Hemophagocytic Lymphohistiocytosis

Principal Investigator Yenan Bryceson, PhD Karolinska Institutet, Stockholm, Sweden Date of Award December 2014 Amount of Award…

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Comprehensive mRNA/miRNAs Expression Analysis in Familial Hemophagocytic Lymphohistiocytosis Type 2, Using the C57BL/6-Prf1tm1Sdz/J Murine Model

Principal Investigator Janos Sumegi, MD, DSc, PhD Cincinnati Children’s Hospital Medical Center, Cincinnati, OH USA Date of…

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Accumulation of Heterozygous Mutations on HLH Pathogenesis

Principal Investigator Fernando Sepulveda, PhD Imagine Institute, Paris, France Date of Award December 2014 Amount of Award…

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Janus Kinase Inhibition as a Novel Treatment for Hemophagocytic Lymphohistiocytosis

Principal Investigator Kim E. Nichols, MD University of Pennsylvania Perelman School of Medicine The Children’s Hospital of…

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Gene Therapy in a Mouse Model of Virus-triggered X-linked Lymphoproliferative Disease (XLP1): Control of Infection and Disease Progression

Principal Investigator Peter Aichele, PhD University Medical Center Freiburg, University of Freiburg – Freiburg, Germany Date of…

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M1 Versus M2 Polarization of the Hemophagocyte: Insight into Biologic Function

Principal Investigator Edward Behrens MD The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania USA Date of Award…

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Improving Diagnostics of and Gaining Mechanistic Insights into Defects in Lymphocyte Cytotoxicity Underlying HLH

Continuation of study funded in 2011 Principal Investigator Yenan Bryceson PhD Karolinska Institutet Center for Infectious Medicine…

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