Grants Awarded

HLH/FEL/FHL
All
  • All
  • HLH/FEL/FHL
  • LCH
  • Rare Histiocytic Disorders and Other Topics
  • RDD

Accumulation of Heterozygous Mutations on HLH Pathogenesis

Principal Investigator Fernando Sepulveda, PhD Imagine Institute, Paris, France Date of Award December 2014 Amount of Award…

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Janus Kinase Inhibition as a Novel Treatment for Hemophagocytic Lymphohistiocytosis

Principal Investigator Kim E. Nichols, MD University of Pennsylvania Perelman School of Medicine The Children’s Hospital of…

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Gene Therapy in a Mouse Model of Virus-triggered X-linked Lymphoproliferative Disease (XLP1): Control of Infection and Disease Progression

Principal Investigator Peter Aichele, PhD University Medical Center Freiburg, University of Freiburg – Freiburg, Germany Date of…

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M1 Versus M2 Polarization of the Hemophagocyte: Insight into Biologic Function

Principal Investigator Edward Behrens MD The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania USA Date of Award…

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Improving Diagnostics of and Gaining Mechanistic Insights into Defects in Lymphocyte Cytotoxicity Underlying HLH

Continuation of study funded in 2011 Principal Investigator Yenan Bryceson PhD Karolinska Institutet Center for Infectious Medicine…

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Focused Screening of Novel Therapies for HLH Using an Animal Model

Principal Investigator Michael Jordan MD Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA Date of Award…

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Perforin Gene Transfer into Human Cytotoxic Lymphocytes

Principal Investigator Kimberly Risma, MD, PhD Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA Date of…

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Mechanistic Studies of Defects in Lymphocyte Cytotoxicity Underlying HLH

Principal Investigator Yenan Bryceson PhD Karolinska Institutet Center for Infectious Medicine – Stockholm, Sweden Date of Award…

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Biomarkers in Primary and Secondary Hemophagocytic Lymphohistiocytosis

Principal Investigator Janos Sumegi MD, PhD Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA Date of…

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Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic Function

Principal Investigator Kimberly Risma MD, PhD Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA Date of…

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